Stephane Houdet's title defence at the US Open Wheelchair Championships is over after the French world number three was beaten by Joachim Gerard in the quarter finals in St Louis.
Belgium's Gerard, the world number six, came from behind to triumph 5-7, 6-3, 6-2 in Missouri.
Houdet had been looking for a fourth straight victory at the Super Series event but his winning streak of 14 matches is now over.
It came on a day when the last four line-up was decided across the events at the Dwight Davis Tennis Center.
Argentina's Gustavo Fernandez, who has lost to Houdet in the past three St Louis finals, also came unstuck as he was defeated via two tiebreaks to Sweden's world number four Stefan Olsson, 7-6, 7-6.
World number one Shingo Kunieda of Japan had no such problems as he beat compatriot Takashi Sanada 7-6, 7-5.
He will now play Olsson, with Britain's Alfie Hewett setting up a meeting with Gerard.
Hewett led 7-5, 4-1 against Japan's Kouhei Suzuki before his opponent retired injured.
In the women's event, Italy's Giulia Capocci claimed a first career win over London 2012 Paralympic champion Marjolein Buis to make her second Super Series semi-final.
The Dutchwoman was knocked out 5-7, 6-2, 6-4 by the world number seven.
Capocci will now meet Japan's world number two Yui Kamiji, a 7-5, 6-2 winner over South African fifth seed Kgothatso Montjane.
Dutch world number one Diede de Groot powered past Colombian Angelica Bernal 6-2, 6-0 and will meet her third-ranked compatriot Aniek van Koot, a 6-3, 6-1 winner over Britain's Lucy Shuker.
In the quads event, home American player David Wagner reached the last four as he beat compatriot Bryan Barten 6-2, 6-1.
He will play Australia's world number four Heath Davidson who came past South Korea's Kyu-Seung Kim, 1-6, 6-2, 6-2.
Britain's defending champion Andy Lapthorne marched on by beating Japan's world number five Koji Sugeno, 6-3, 6-3.
The world number three will play the world number two as Australia's Dylan Alcott beat Japan's Mitsuteru Moroishi 6-2, 6-1.
This is a repeat of the Rio 2016 Paralympic final, won by Alcott.
The last Super Series event of the season continues tomorrow.
It is a warm-up tournament for the US Open, the final Grand Slam competition of the year.