Serena Williams came out on top in a battle of the former US Open champions when she recovered from a set down to beat fellow American Sloane Stephens and reach the last 16 of this year's tournament at Flushing Meadows in New York City.
Greek number four seed Stefanos Tsitsipas is out of the US Open after a five-set defeat to Borna Coric of Croatia in round three, but Novak Djokovic advanced.
Former champion Naomi Osaka battled past promising Ukrainian teenager Marta Kostyuk to reach the fourth round of the US Open in New York City.
Two more women's top ten seeds were defeated on the fourth day of the US Open, as Britain's Johanna Konta and Spain's Garbiñe Muguruza both lost during the day session at Flushing Meadows in New York.
Andy Murray crashed out of the US Open following a convincing second-round defeat to Felix Auger-Aliassime, but insists he will still "shoot for the stars" in his bid to win a Grand Slam title again.
Fourth seed Naomi Osaka of Japan cruised into the third round of the US Open with a straight-sets victory over Italian Camila Giorgi in New York City.
There were mixed fortunes for the number one seeds on day three of the US Open, as men's world number one Novak Djokovic won through in four sets but women's top seed Karolina Pliskova suffered a shock exit.
Australian Open tournament director Craig Tiley believes "all the top players" will be in Melbourne for the first tennis Grand Slam of 2021.
Russia's Daniil Medvedev eased into the second round at the US Open by securing a straight sets win over Argentina's Federico Delbonis at Flushing Meadows.
Britain's Andy Murray battled back from two sets down to win a five set thriller against Japan's Yoshihito Nishioka on day two of the US Open.
Women's top seed Karolína Plíšková recorded a straight-sets win on the first day of the US Open, as the second Grand Slam tennis tournament of the year got underway in New York.
Top seed Novak Djokovic breezed past Damir Džumhur to reach the second round of the US Open, while former women's champion Naomi Osaka is also into round two.
The US Open is set to get underway tomorrow following weeks of high-profile withdrawals due to concerns surrounding the coronavirus pandemic.
Men's world number one Novak Djokovic has resigned as President of the Association of Tennis Professionals (ATP) Players Council to form a new players' association, leading to criticism from some high-profile players and tennis bodies.
Novak Djokovic equalled Rafael Nadal's record of 35 Masters Series 1000 titles after coming from a set down to beat Milos Raonic in the final of the Cincinnati Masters.