Vanuatu lost to Papua New Guinea by 57 runs in front of their home crowd at the first match of the International Cricket Council Women's Qualifier East-Asia Pacific (EAP) 2019.
Papua New Guinea totalled 144 for four in their 20 overs at Independence Park Ground One in Port Vila.
They were then back in action in the afternoon session, beating Indonesia by seven wickets.
Papua New Guinea had been expected to dominate the tournament, having won the previous three regional events.
They will play Fiji tomorrow, while Samoa take on Japan.
The hosts then meet Fiji, with Indonesia facing Samoa.
At the ICC Women's Qualifier Africa 2019 in Harare, hosts Zimbabwe attained their second victory of the competition.
They managed 143 for four in 20 overs against Tanzania, winning by 92 runs.
In the remaining Group A fixture, Mozambique beat Nigeria by eight wickets.
In Group B, Kenya thrashed Sierra Leone by 106 runs, while Namibia narrowly beat Uganda by 14 runs.
The best teams from the African and Asian competitions will earn a place at the ICC Women’s T20 World Cup Qualifier 2019 and the ICC Women’s Cricket World Cup Qualifier 2020.
The Women’s T20 World Cup Qualifier is due to take place in Scotland between August 31 and September 7, with Bangladesh, Ireland, Scotland and Thailand confirmed participants.
The location and dates of the Women's Cricket World Cup Qualifier are yet to be decided, but Bangladesh, Ireland, Thailand and Sri Lanka have already booked their places.